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KMID : 0358419740170100375
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Korean Journal of Obstetrics and Gynecology
1974 Volume.17 No. 10 p.375 ~ p.381
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The Morphologic Effect of Estrogen on the Rat Pituitary (LTH) Cell
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Abstract
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The recent great increase in the use of female sex hormones particularly for contraception and for the treatment of gynecological problems makes it necessary to further study the side reactions and complications of the female sex hormones.
Estrogen is one of the most important hormones used clinically. It has a significant effect on. the pituitary gland function, particularly on the feed-back mechanism of the Neuro-hypothalamo-pituitary-ovarian-endometrial axis.
Using electron microscopy, this study investigated the morphological changes in the LTH cells of the anterior pituitary. of rats following the administraion of estrogen.
Extrogen-morphological effect was observed in three groups of rats
Group I was the control group which received 0.5cc saline intramuscularly daily. Group II received 0.05 /kg of estrogen. IM daily.
Group III were givenO. 2 mglk of estrogen, IM daily. Results
1) As the dose of estrogen was increased there was a parallel decrease in the body weight;
2) As the dose of estrogen was increased there was a parallel. increase in the weight of the pituitary gland. 3) After veeks for Group TI and 1 week for Group III the following morphological changes were noted following estrogen administration: (1) Nuclear enlargement.
(2) Increased xnitochrondria.
(3) )Expansion of the Golgi membrane.
(4) Decraased secretion granules
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